Am J Obstet Gynecol. The truth is, there just isnt enough research yet to know exactly how massage gun use compares to a traditional hands-on massage. Mjosberg J, Svensson J, Johansson E, et al. J Gastroenterol Hepatol. Furthermore, there was no significant difference in the ratio of IFN--secreting T cells to IL-10-secreting T cells between two groups (Fig.5C-5F). massagegunadvice.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking toAmazon.com. Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-b. This work was supported by National Key Research and Development Program of China (No. Their high amplitude makes them best suited for a true deep-tissue massage, but remember that this means they percuss less intensively (up to 2450 hits per minute). In Vivo. Boeijen LL, Spaan M, Boonstra A. Prophylactic antiviral intervention during pregnancy has an effect on T cell immunity in pregnant women, which was characterised by increased maternal Treg frequency, enhanced Th2 response and suppressed Th1 response at delivery. Continuous maternal administration of magnesium sulfate in pregnancy beyond 5 to 7 days can cause fetal abnormalities. PubMedGoogle Scholar. Hepatology. 1994 Nov;11(6):427-9. doi: 10.1055/s-2007-994612. 2005;41:7718. It can be mild or severe. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. The effects of nucleoside/nucleotide analogues on host immune cells: the baseline for future immune therapy for HBV? Liu J, Wang J, Jin D, et al. https://doi.org/10.1186/s12884-023-05700-8, DOI: https://doi.org/10.1186/s12884-023-05700-8. Data Sources: A PubMed search was completed in Clinical Queries using key terms including preeclampsia, eclampsia, and gestational hypertension. These results showed that maternal Treg frequency in pregnant women with HBV infection at delivery was lower than that of non-pregnant women with HBV infection and maternal antiviral intervention had effect of increasing maternal Treg frequency in pregnant women with HBV infection at delivery. The data that support the findings of this study are available from the corresponding author upon reasonable request. Hepatic flare after telbivudine withdrawal and efficacy of postpartum antiviral therapy for pregnancies with chronic hepatitis B virus. Best Value Massage Gun of 2023 Our Top Picks from Personal Experience, Most Powerful Massage Guns: When the Mighty Lock Horns, Best Budget Massage Guns Cheapest (But Still Good) Options, And Things To Know About. To provide evidence for managing chronic HBV-infected pregnant women, it is needed to explore alteration of T cell immunity caused by antiviral intervention. Delivery is generally indicated at 37 weeks' gestation for women who have gestational hypertension or preeclampsia without severe features. Background Evidence regarding adverse pregnancy outcomes in patients with thyroid cancer has been conflicting, and the effect of thyroid dysfunction caused by thyroid hormone suppression therapy in terms of neonatal thyroid stimulating hormone (TSH) is unclear. 2014;5:253. A serum magnesium level of 6 mg/100 mL is considered optimal for seizure control. Part of However, 1518weeks after delivery, maternal HBeAg level was positively correlated with Treg frequency in AVI group (P=0.034, r=0.532), but a similar correlation was not observed between Treg frequency and HBsAg (see supplementary Fig.S1A and Fig.S1B). Hopefully this article helps in answering the question: are massage guns safe during pregnancy? 2020;50(4):43952. Evidence for a Selective Migration of Fetus-Specific CD4+CD25bright Regulatory T Cells from the Peripheral Blood to the Decidua in Human Pregnancy. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. However, in the special milieu of pregnancy, the immune system of mother with lower levels of HBsAg or HBeAg requires higher Treg frequency to maintain immunotolerance, so that Treg frequency in the AVI group was negatively correlated with maternal HBsAg or HBeAg levels at delivery and positively correlated with maternal HBsAg or HBeAg levels after delivery. The NNT falls to 19 among those at greatest risk. Previous studies have shown that antiviral therapy with nucleot(s)ide analogues (NAs) could impact on T cell immunity of chronic hepatitis B patients [26]. In various stages of pregnancy, the balance between pro-inflammatory and anti-inflammatory of pregnant women is dynamically modulated. Countdown to 2030: eliminating hepatitis B disease, China. We are reader-supported, and if you buy via our links, we may earn a commission. Article While the M3 Pro 2 uses the classic T-shape, the Apex uses an angled handle for improved ergonomics. Treg frequency and the abilities of cytokines secretion were similar between the AVI group and NAVI group after withdrawal treatment postpartum, and the second time antiviral intervention during another pregnancy had no superposition effect on Treg frequency, that is, the influence of the antiviral intervention in the third trimester on maternal T cells was not sustained after delivery. Some other things to consider choosing between Theragun and Hypervolt: Based on our experience with both brands products, we think Hypervolt attachments are better varied than Theragun options overall, but keep in mind that theyre all hard plastic with the exception of the standard semi-soft ball. Low-dose aspirin can reduce the 2005 Aug;193(2):421-5. doi: 10.1016/j.ajog.2004.12.023. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. r represents the correlation coefficient. This result indicated that high frequency of Treg in the intervention mothers suggests a relative balance between pro-inflammation and anti Following fixation and permeabilisation (BD Biosciences) for 20min, surface-stained cells were incubated with the following antibodies for 30min: PECy7-conjugated anti-interferon (IFN)- (clone B27; BD Biosciences), PE-conjugated anti-interleukin (IL)-10 (clone JES3-9D7; Biolegend), PE-conjugated anti-IL-21 (clone 3A3-N2.1; BD Biosciences), APC-conjugated anti-tumour necrosis factor (TNF)- (clone 6401.1111; BD Biosciences), PE-conjugated anti-IL-2 (clone MQ1-17H12; BD Biosciences), and PECy7-conjugated anti-IL-4 (clone 8D4-8; BD Biosciences). Therefore, we investigated the effects of antiviral intervention during pregnancy on T cell immunity of chronic HBV-infected mothers. The study protocol was approved by the institutional ethics committee of the Nanfang Hospital (NFEC-2019197), and written informed consent was obtained from all subjects. If any of the following problems come up during your pregnancy, massage may not be a safe option for you: Its always important to listen to your body when trying new self-care techniques, massage guns included, so be sure to use caution and be gentle. Magnesium levels in patients with preeclampsia were not significantly different from controls. J Pregnancy. 2011;54(2):20918. PubMed Central Although a variety of tocolytics are used in clinical practice, magnesium sulfate remains one of the most commonly used agents. Safe Practice Recommendations To reduce the risk of harm when administering magnesium sulfate to obstetrical patients, consider the following: (B)Percentages of cytokine-producing CD4+ T cells in intervention (n=34) or non-intervention (n=15) mothers, and (C) the data represent Th1:Th2-cytokine ratio (IFN-:IL-10) in CD4+ T cells. Although it might be tempting to go after the aches and pains in your lower back after all, this is a very common area of discomfort for many women during pregnancy you will need to avoid your lower back because direct force over this area will also cause unwanted vibration around your developing baby. This allows drugs Effect of therapeutic massage on relieving pregnancy discomforts. Timing of delivery is based on a combination of factors, including disease severity, maternal and fetal condition, and gestational age. 2018 Jun;11(2):67-72. doi: 10.1177/1753495X17744478. 2012;18(34):467783. The data represent the median with 95% CI. We also think that the Theragun mini is a nice option for relieving some muscle tension while keeping your massage on the gentle side. Theragun isnt the only established massage gun name in the market today, and Hyperices Hypervolt may be considered their top competitor. At delivery, maternal regulatory T cell (Treg) frequency in AVI mothers was significantly higher than that in NAVI mothers (P<0.002), and CD4+ T cells in AVI mothers displayed a decreased ability to secrete IFN- (P=0.005) and IL-21 (P=0.043), but an increased ability to secrete IL-10 and IL-4 (P=0.040 and P=0.036), which represented a higher Treg frequency, enhanced Th2 response and suppressed Th1 response. Medically reviewed by Dr. Gary Tanchak, D.C. What To Know: our content is non-sponsored and fact-checked for accuracy. Serological marker and HBV DNA assays were performed at the Laboratory of Viral Hepatitis Research, Nanfang Hospital. The .gov means its official. Wang M, Bian Q, Zhu Y, et al. However, observation of hypomagnesemia for this and other etiologies just prior to the initiation of preterm labor were not available. MORE INFO For more details, check out our in-depth reviews: Ekrin B37 review and Ekrin 365 review. Why not? 2006;332:32836. World J Gastroenterol. The site is secure. An increasingly common question among fans of massage guns is: can you use a massage gun while pregnant? Lancet. Analyses were performed using the BD FACSDiva system (BD Biosciences) and the FlowJo software (TreeStar Inc.). LAWRENCE LEEMAN, MD, MPH, LEE T. DRESANG, MD, AND PATRICIA FONTAINE, MD, MS. Springer Nature. Liu C, Xu L, Xia C, et al. It will be well enough for use on your arms and back. Cite this article. EASL. Okunade KS, Oluwole AA, Adegbesan-Omilabu MA. IOSR Journal of Nursing and Health Science. The ideal medication for prevention and treatment of migraine would have no side effects, no risk, would be safe in pregnancy, as well as be highly effective while remaining inexpensive. J Hepatol. We followed up 20 intervention mothers and 6 non-intervention mothers at 68 and 1518weeks after postpartum, respectively. Google Scholar. In this study, we examined the effects of antiviral intervention on maternal T cell immunity during pregnancy by comparing mothers who received antiviral intervention with those who did not, and investigate whether this effect is sustainable by comparing differences of T cells immunity between the intervention and non-intervention mothers after drug withdrawal postpartum. [updated July 27 2021]. Stoop JN, van der Molen RG, Baan CC, et al. Another study administered magnesium (100 mg) also to 2023 BioMed Central Ltd unless otherwise stated. J Infect Dis. Effect of prophylactic antiviral intervention on T cell immunity in hepatitis B virus-infected pregnant women, https://doi.org/10.1186/s12884-023-05700-8, https://www.who.int/news-room/fact-sheets/detail/hepatitis-b, https://www.who.int/publications/i/item/978-92-4-000270-8, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, bmcpregnancyandchildbirth@biomedcentral.com. All authors read and approved the final manuscript. 2020;8:1. Our team, steeped in experience and driven by passion, personally tests and assesses each product. Amazon and the Amazon logo are trademarks of Amazon.com, Inc. or its affiliates. PubMed Central Treg frequency among AVI mothers was correlated negatively with serum HBsAg and HBeAg levels. Here, we present a secondary analysis of data pooled from four large observational studies that assessed magnesium Adv Med. 2001-2023 BabyMed.com - All Rights Reserved. If youre still unsure about using your massage gun during pregnancy, we recommend scheduling an appointment with a licensed massage therapist who specializes in pregnancy care. Delivery timing involves balancing the risks of prematurity against worsening preeclampsia. Another solid option is their Ekrin B37 a slightly more robust model with more power. We did not find significant difference in HBsAg and HBeAg level between the two groups. Prevention of mother-to-child transmission of hepatitis B virus: guidelines on antiviral prophylaxis in pregnancy. The optimal BP for women with severe preeclampsia is unknown. Hepatitis B virus infection in children and adolescents. Would you like email updates of new search results? Intravenous labetalol or hydralazine or oral nifedipine may be used to treat severe hypertension during pregnancy. However, the immunological characteristics of pregnant women with chronic HBV infection and the effects of antiviral intervention during pregnancy on maternal immune response remain unknown. In our opinion the best Theragun while pregnant is the Theragun Prime. Bookshelf Calcium supplementation may decrease the incidence of hypertension, preeclampsia, and mortality among high-risk women with low calcium intake. According to the CDCs Pregnancy Mortality Surveillance System, hypertensive disorders account for 11.1% of all causes of pregnancy-related death in the United States during the 20062007 period. Magnesium sulfate is more effective than diazepam (Valium) or phenytoin (Dilantin) for preventing recurrent eclamptic seizures and decreasing maternal mortality. We believe the best Hypervolt while pregnant is the Hypervolt 2. Previous studies have showed that Th1 and Th2 responses during various stages of pregnancy are dynamically regulated, and during parturition, the last phase of pregnancy, the pro-inflammatory milieu, especially Th1 response, is predominant [25]. https://www.who.int/publications/i/item/978-92-4-000270-8.Accessed 24 Dec 2021. From: Kendig's Disorders of the Respiratory Tract in Children (Seventh Edition), 2006 View all Topics Add to Mendeley He currently practices orthopedics in Bellevue Washington and manages an online health coaching business via social media (@dr.alexstone). All Rights Reserved. A total of 49 HBV-infected mothers were enrolled at delivery at the Nanfang Hospital, including 34 mothers who received prophylactic antiviral intervention from gestation weeks 26 to 28 until delivery to prevent MTCT (AVI group) and 15 of those who did not (NAVI group). J Immunol. Prophylactic antiviral intervention in late pregnancy had no significant effect on maternal T cells after delivery (A)Comparison of the difference in Treg frequency in intervention mothers (n=20) with non-intervention mothers (n=6) at postpartum 68weeks or 1518weeks; (B)Treg frequency changes before, during and after withdrawal of antiviral drugs in a chronic HBV infected mother during the first and second pregnancy; (C-D)Percentages of cytokine-producing CD4+T cells in intervention (n=20) or non-intervention (n=6) mothers at postpartum 68 or 1518weeks, respectively and the data represent Th1:Th2-cytokine ratio (IFN-:IL-10) in CD4+T cells. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Hepatology. Urine output should be maintained above 30 mL per hour, and a Foley catheter should be used to monitor urine output if MgSO4 is administered.28 Total intravenous intake should be less than 100 mL per hour, and total combined oral and intravenous fluids should be less than 125 mL per hour.28. WebRDA: The Recommended Dietary Allowance (RDA) for adults 19-51+ years is 400-420 mg daily for men and 310-320 mg for women. Magnesium Sulfate Infusion Therapy, Pre-eclampsia Purpose: Magnesium sulfate should be used for the prevention and treatment of seizures in women with severe Furthermore, the extent of immunotolerance may be related to HBsAg or HBeAg levels. Between 24 and 34 weeks' gestation, fetal lung maturity may be accelerated by the use of betamethasone (two 12-mg intramuscular doses given 24 hours apart) or dexamethasone (four 6-mg intramuscular doses given 12 hours apart).37, Delivery route and timing are based on maternal factors (e.g., disease progression, parity, cervical examination findings) and fetal considerations (e.g., gestational age, antenatal testing).38,39 Data are limited about expectant management of women who have preeclampsia with severe features between 24 and 34 weeks' gestation.40 Expectant management in a hospital with perinatal and neonatology services decreases neonatal morbidity and intensive care unit stay. Pregnancy requires about 350-360 mg daily and lactation, 310-320 mg. UL: The Tolerable Upper Intake Level is the maximum daily intake unlikely to cause harmful effects on health. Pregnancy Trimester One: 1.6 to 2.2 mg/dL or 1.33 Previous studies showed that treatment of CHB patients with NAs reduced Treg frequency and restored host immunity against HBV, which was associated with an upregulated Th1 response [30, 34, 35]. Most things are safe in moderation, but knowing how much is too much can be the difference between safe and unsafe treatment. Women with gestational hypertension or preeclampsia without severe features should have planned delivery at 37 weeks' gestation. May 18, 2023 Added links to individual reviews; minor edits and corrections (By: Luke), April 10, 2023 New photos of Theragun, Opove (By: Greg), February 25, 2023 Added specs comparison tables (By: Luke), November 6, 2022 New device photos added (By: Greg), August 19, 2022 Fact-checked and reviewed for accuracy (By: Dr. Gary Tanchak, D.C), Alex Stone is a Doctor of Physical Therapy and Certified Strength and Conditioning Specialist (NSCA). Ekrin is a young and aspiring American brand that offers many great, slightly more vibrational alternatives to Theragun and Hypverolt. In many ways, the effects of your massage gun can be compared to a deep tissue massage. doi:10.1186/s12884-020-02924-w. Unauthorized use of these marks is strictly prohibited. All devices listed in this articles have been personally tested by us. Having experimented with most options on the market today, we can recommend some strong competition at a lower price point. This site needs JavaScript to work properly. Among pregnant women in the AVI group, no significant difference in Treg frequency was noted among those with telbivudine (LDT, n=24) or tenofovir (TDF, n=10) intervention (P>0.05) (Fig.2C). A disseminated intravascular coagulation workup (fibrinogen, prothrombin time, partial thromboplastin time) should be ordered for women with abnormal bleeding or a platelet count less than 50 103 per L (50 109 per L). The main difference between Theragun models is their stall force (the force required to stop the motor from revving). 2016;44(10):100517. If youre unsure about how low to go, talk to your medical doctor. 2017 Oct 16;9(10):1125. doi: 10.3390/nu9101125. Dealing with body changes and pregnancy-related stress can increase tension through your neck and shoulders, and this area usually responds well to a good massage. Antivir Ther. Chatterjee P, Chiasson VL, Bounds KR, Mitchell BM. Pregnant women positive for hepatitis B surface antigen and hepatitis B e-antigen (HBsAg+ HBeAg+) were enrolled at delivery, including 34 received prophylactic antiviral intervention during pregnancy (AVI mothers) and 15 did not (NAVI mothers). Accessed 24 Dec 2021. The measurement of serum magnesium is the most widely used method for determining magnesium levels, but it has significant limitations that have both hindered volume23, Articlenumber:392 (2023) Preeclampsia is a risk factor for future cardiovascular disease, especially if it occurs in multiple pregnancies or is associated with intrauterine growth restriction or required delivery before 37 weeks' gestation.1 Prevention or treatment of comorbidities for cardiovascular disease is recommended. The former has a 14.5mm amplitude, so it will be more similar to high-end options like the Hypervolt 2 Pro and mid-range Theraguns. Another important factor is the intensity of your massage gun use. Women with hypertensive disorders should be monitored as inpatients or closely at home for 72 hours postpartum. An accumulating body of literature indicates that magnesium deficiency is associated with a number of hormone-related conditions (HRC) in women, and epidemiological studies are needed to assess its prevalence and risk factors. 2009;183:75969. Epub 2016 Jul 21. 2021;21(1):922. The baseline characteristics of pregnant women with chronic HBV infection in the two groups were showed in Table 2. Elevated blood pressure in pregnancy may represent chronic hypertension (occurring before 20 weeks' gestation or persisting longer than 12 weeks after delivery), gestational hypertension (occurring after 20 weeks' gestation), preeclampsia, or preeclampsia superimposed on chronic hypertension. If you can afford the high ticket price, they may be the best massage gun option for you during your pregnancy. 2018;38:1225. Please refer to ourPrivacy & Affiliate Policyfor details. Massage Gun Advice team is committed to provide the highest quality articles and information which follows the highest editorial standards. Proteinuria is not essential for diagnosis if a severe feature is present. Furthermore, magnesium is vital for a healthy pregnancy. PI was used in the Live/Dead Fixable dead cell stain kit to separate living cells. Required fields are marked *. BTreg frequency in intervention mothers (n=34), non-intervention mothers (n=15), and HBsAg+ HBeAg+ non-pregnant women (IT, n=3). BMC Pregnancy and Childbirth

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